OBO ID: CHEBI:167672

Term Name:	TAK-580		Search Ontology:
Synonyms:	2-[(1R)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-N-[5-chloro-4-(trifluoromethyl)pyridin-2-yl]-1,3-thiazole-5-carboxamide 6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide AMG 2112819 AMG-2112819 AMG2112819 BIIB 024 BIIB-024 BIIB024 DAY101 MLN 2480 MLN-2480 MLN2480 TAK 580 TAK580
Definition:	A 1,3-thiazolecarboxamide that is 2-[(1R)-1-aminoethyl]-1,3-thiazole-5-carboxylic acid in which the carboxy group undergoes formal condensation with the amino group of 5-chloro-4-(trifluoromethyl)pyridin-2-amine and in which the amino group undergoes formal condensation with the carboxy group of 6-amino-5-chloropyrimidine-4-carboxylic acid. It is a pan-RAF kinase inhibitor which is currently in clinical development for the treatment of radiographically recurrent or progressive low-grade glioma in children and young adults.
References:	CAS:1096708-71-2 Chemspider:28637796 DrugBank:DB15266 LINCS:LSM-45644 PDBeChem:QOP PMCID:PMC6012010 PMCID:PMC7715228 PMCID:PMC7715396 PMID:27768280 PMID:28082416 PMID:30622172 PMID:32588846 PMID:33216827 Patent:US20090036419
Ontology:	ChEBI  ( EBI )