OBO ID: CHEBI:167670

Term Name:	SCH772984		Search Ontology:
Synonyms:	(3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-1H-indazol-5-yl]pyrrolidine-3-carboxamide (3R)-1-[2-oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide SCH 772984 SCH-772984
Definition:	A member of the class of indazoles that is 1H-indazole substituted by pyridin-4-yl and {[(3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)pyrrolidin-3-yl]carbonyl}amino groups at positions 3 and 5, respectively. It is a potent inhibitor of mitogen-activated protein kinases ERK1 and ERK2 (IC50 = 4 and 1 nM, respectively) that exhibits anti-cancer properties.
References:	CAS:942183-80-4 LINCS:LSM-45224 PDBeChem:38Z PDBeChem:F3Z PMID:23847348 PMID:25142146 PMID:25195011 PMID:26832798 PMID:27275127 PMID:28781955 PMID:29193645 PMID:29262554 PMID:29775310 PMID:30915617 PMID:31055884 PMID:31311868 PMID:32652503 PMID:32821122 PMID:33105944 PMID:33151174 PMID:33231464 PMID:33258389 PMID:33595872 PMID:33692846 PMID:33706642
Ontology:	ChEBI  ( EBI )