OBO ID: CHEBI:167658

Term Name:	CP-724714		Search Ontology:
Synonyms:	(E)-2-methoxy-N-[3-[4-[[3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl]amino]quinazolin-6-yl]allyl]ethanamide 2-methoxy-N-[(2E)-3-(4-{3-methyl-4-[(6-methylpyridin-3-yl)oxy]anilino}quinazolin-6-yl)prop-2-en-1-yl]acetamide 2-methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]-acetamide 2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]acetamide CP 724714 CP-724,714 CP724714
Definition:	A 2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide in which the double bond adopts a trans-configuration. It is a potent inhibitor of HER2/ErbB2 (IC50 = 10 nM) and exhibits anti-cancer activity.
References:	CAS:845680-17-3 Chemspider:8050601 DrugBank:DB12302 LINCS:LSM-42777 PMID:17285315 PMID:17317835 PMID:17805538 PMID:17942920 PMID:18500794 PMID:19223659 PMID:25426072 PMID:26846307 PMID:28014873 PMID:28902361 PMID:29662626 PMID:30858165 PMID:31613219 PMID:33463944
Ontology:	ChEBI  ( EBI )