OBO ID: CHEBI:167655

Term Name:	BMS-214662		Search Ontology:
Synonyms:	(3R)-3-benzyl-1-(1H-imidazol-5-ylmethyl)-4-(thiophen-2-ylsulfonyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile (3R)-3-benzyl-1-(1H-imidazol-5-ylmethyl)-4-thiophen-2-ylsulfonyl-3,5-dihydro-2H-1,4-benzodiazepine-7-carbonitrile (R)-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine-7-carbonitrile (R)-7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine BMS 214662 BMS214662
Definition:	A member of the class of benzodiazepines that is 2,3,4,5-tetrahydro-1H-1,4-benzodiazepine substituted by (1H-imidazol-5-yl)methyl, benzyl, (thiophen-2-yl)sulfonyl, and cyano groups at positions 1, 3R, 4 and 7, respectively. It is a potent inhibitor of farnesyltransferase (IC50 = 1.35nM) which was under clinical development for the treatment of solid tumors.
References:	CAS:195987-41-8 Chemspider:395310 DrugBank:DB12234 PDBeChem:BMV PMID:11020273 PMID:11606387 PMID:12789624 PMID:15073096 PMID:15102665 PMID:15170324 PMID:15356656 PMID:15710949 PMID:15728224 PMID:15738311 PMID:15756013 PMID:15930351 PMID:16362299 PMID:17510207 PMID:17956348 PMID:18156496 PMID:19738029 PMID:19883257 PMID:21483442 PMID:23184491 PMID:27688185
Ontology:	ChEBI  ( EBI )