OBO ID: CHEBI:167652

Term Name:	AZD2858		Search Ontology:
Synonyms:	3-amino-6-[4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-N-3-pyridinyl-2-pyrazinecarboxamide 3-amino-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-N-(pyridin-3-yl)pyrazine-2-carboxamide AZD 2858 AZD-2858
Definition:	A member of the class of pyrazines that is pyrazine substituted by (pyridin-3-yl)aminocarbonyl, amino, and 4-(4-methylpiperazine-1-sulfonyl)phenyl groups at positions 2, 3 and 6, respectively. It is a potent inhibitor of GSK3alpha and GSK3beta (IC50 values of 0.9 and 4.9 nM, respectively) and increases bone mass (via Wnt activation) in rats.
References:	CAS:486424-20-8 Chemspider:8314492 PDBeChem:GR9 PMCID:PMC4200977 PMCID:PMC6795005 PMID:22142634 PMID:22489897 PMID:23337038 PMID:23872097 PMID:27789709 PMID:28881139
Ontology:	ChEBI  ( EBI )