OBO ID: CHEBI:167651

Term Name:	AZD1080		Search Ontology:
Synonyms:	2-hydroxy-3-[5-(4-morpholinylmethyl)-2-pyridinyl]-1H-indole-5-carbonitrile 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile AZ-11548415 AZD 1080 AZD-1080
Definition:	A member of the class of hydroxyindoles that is 1H-indole substituted by hydroxy, 5-(morpholin-4-ylmethyl)pyridin-2-yl, and cyano groups at positions 2, 3 and 5, respectively. It is a potent, brain permeable inhibitor of human GSK3alpha and GSK3beta with Ki of 6.9 nM and 31 nM, respectively. The drug was being developed by AstraZeneca for the treatment of Alzheimer's disease (clinical trial now discontinued).
References:	CAS:612487-72-6 Chemspider:24808514 PMID:23410232 PMID:27050373 PMID:27051274 PMID:32184604 PMID:33422940
Ontology:	ChEBI  ( EBI )