OBO ID: CHEBI:166834

Term Name:	MLN-4760		Search Ontology:
Synonyms:	(S,S)-2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)-ethylamino)-4-methylpentanoic acid 2(S)-(1(S)-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)-ethylamino)-4-methylpentanoic acid GL-1001 GL1001 MLN4760 N-[(1S)-1-carboxy-3-methylbutyl]-3-(3,5-dichlorobenzyl)-L-histidine N-[(1S)-1-carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]-L-histidine ORE-1001 ORE-1001 free acid ORE1001
Definition:	A L-histidine derivative that is L-histidine in which a hydrogen of the primary amino group is substituted by a (1S)-1-carboxy-3-methylbutyl group and the ring NH group is substituted by a 3,5-dichlorobenzyl group. It is a potent and selective human angiotensin-converting enzyme 2 (ACE2) inhibitor (IC50 = 0.44 nM) which was in clinical development for the treatment of ulcerative colitis.
References:	CAS:305335-31-3 Chemspider:395128 DrugBank:DB12271 LINCS:LSM-45511 PDBeChem:XX5 PMID:14754895 PMID:18243695 PMID:18324760 PMID:18356558 PMID:19517214 PMID:26851370 PMID:27302421 PMID:30806090 PMID:31356776 PMID:31393582 PMID:32368013 PMID:32866470 PMID:33122196
Ontology:	ChEBI  ( EBI )