OBO ID: CHEBI:145372

Term Name:	gilteritinib		Search Ontology:
Synonyms:	6-ethyl-3-((3-methoxy-4-(4-(4-methyl-1-piperazinyl)-1-piperidinyl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)-2-pyrazinecarboxamide 6-ethyl-3-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino}-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide 6-ethyl-3-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino}-5-[(oxan-4-yl)amino]pyrazine-2-carboxamide ASP 2215 ASP-2215 ASP2215 gilteritinib gilteritinibum Xospata
Definition:	A member of the class of pyrazines that is pyrazine-2-carboxamide which is substituted by {3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}nitrilo, (oxan-4-yl)nitrilo and ethyl groups at positions 3,5 and 6, respectively. It is a potent inhibitor of FLT3 and AXL tyrosine kinase receptors (IC50 = 0.29 nM and 0.73 nM, respectively). Approved by the FDA for the treatment of acute myeloid leukemia in patients who have a FLT3 gene mutation.
References:	CAS:1254053-43-4 DrugBank:DB12141 KEGG:D10709 PMCID:PMC6817455 PMID:26279055 PMID:27908881 PMID:28516360 PMID:28645776 PMID:29498296 PMID:30039554 PMID:30514344 PMID:30721452 PMID:30936061 PMID:31069015 PMID:31122910 PMID:31203997 PMID:31320594 PMID:31454267 PMID:31469903 PMID:31528345 PMID:31665578 PMID:31692922 Wikipedia:Gilteritinib
Ontology:	ChEBI  ( EBI )