OBO ID: CHEBI:143117

Term Name:	lorlatinib		Search Ontology:
Synonyms:	(10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile loratinib Lorbrena lorlatinib lorlatinibum PF-06463922 PF06463922 PFE-PKIS 10
Definition:	A cyclic ether that is 16,17-dihydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one substituted by methyl groups at positions 2 and 10R, and by cyano, amino and fluoro groups at positions 3, 7 and 12 respectively. It is a small molecule inhibitor of ALK and ROS1 kinase developed by Pfizer for the treatment of ALK-positive non-small cell lung cancer.
References:	CAS:1454846-35-5 DrugBank:DB12130 KEGG:D11012 PDBeChem:5P8 PMID:24819116 PMID:25073473 PMID:25349124 PMID:25733882 PMID:26698910 PMID:26880581 PMID:27413712 PMID:28594000 PMID:29744867 PMID:30413378 PMID:30478428 PMID:30604291 PMID:30816885 Wikipedia:Lorlatinib
Ontology:	ChEBI  ( EBI )