OBO ID: CHEBI:119573

Term Name:	delavirdine		Search Ontology:
Synonyms:	(N-[2-[4-[3-(1-methylethylamino)pyridin-2-yl]piperazin-1-yl]carbonyl-1H-indol-5-yl] methanesulfonamide) 1-(3-((1-methylethyl)amino)-2-pyridinyl)-4-((5-((methylsulfonyl)amino)-1H-indol-2-yl)carbonyl)piperazine 2-(4-(5-methanesulfonamido-1H-indol-2-ylcarbonyl)-1-piperazinyl)-N-(1-methylethyl)-3-pyridinamine delavirdine N-(2-(1-(3-(isopropylamino)pyridin-2-yl)piperazine-4-carbonyl)-1H-indol-5-yl)methanesulfonamide N-[2-({4-[3-(propan-2-ylamino)pyridin-2-yl]piperazin-1-yl}carbonyl)-1H-indol-5-yl]methanesulfonamide N-{2-[4-(3-Isopropylamino-pyridin-2-yl)-piperazine-1-carbonyl]-1H-indol-5-yl}-methanesulfonamide
Definition:	The amide resulting from the formal condensation of 5-[(methylsulfonyl)amino]-1H-indole-2-carboxylic acid and 4-amino group of 1-[3-(isopropylamino)pyridin-2-yl]piperazine, delavirdine is a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Viral resistance emerges rapidly when delavirdine is used alone, so it is therefore used (as the methanesulfonic acid salt) with other antiretrovirals for combination therapy of HIV infection.
References:	Beilstein:6356813 CAS:136817-59-9 DrugBank:DB00705 Drug_Central:799 KEGG:C06941 KEGG:D07782 PDBeChem:SPP PMID:11124228 PMID:11225565 PMID:11327199 PMID:11363651 PMID:11363709 PMID:11364022 PMID:11364099 PMID:11364363 PMID:11364481 PMID:11590527 PMID:16449090 PMID:21080015 PMID:21683601 PMID:21865017 Patent:WO9109849 Reaxys:6356813 Wikipedia:Delavirdine
Ontology:	ChEBI  ( EBI )