Term Name: NMD_triggering_variant
Synonyms: NMD triggering variant, nonsense-mediated decay triggering variant
Definition: A sequence variant that leads to a change in the location of a termination codon in a transcript that leads to nonsense-mediated decay (NMD). The change in location of a termination codon can be caused by several different types of sequence variants, including stop_gained (SO:0001587), frameshift_variant (SO:0001589), splice_donor_variant (SO:0001575), and splice_acceptor_variant (SO:0001574) types of variants.
Ontology: Sequence Ontology [SO:0002319]

Relationships
is a type of: functionally_abnormal
has subtype: frameshift_variant_NMD_triggering splice_acceptor_variant_NMD_triggering splice_donor_variant_NMD_triggering stop_gained_NMD_triggering