Term Name: | positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate |
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Synonyms: | cardiac muscarinic receptor signaling via Gbeta/gamma, Gbeta/gamma-coupled muscarinic receptor signaling pathway involved in negative regulation of heart rate, muscarinic receptor signaling pathway involved in activation of IKACH, muscarinic receptor signaling pathway involved in ion channel activation, positive regulation of IKACh channel activity by G-protein coupled acetylcholine receptor signaling |
Definition: | A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through activation of the IKACh potassium channel. Binding of acetylcholine to a G protein-coupled acetylcholine receptor (muscarinic receptor) on the surface of the signal-receiving cell results in liberation of the G-beta/gamma complex from the alpha subunit. The G-beta/gamma complex binds directly to the inward-rectifying potassium channel IKACh. Once the ion channel is activated, potassium ions (K+) flow out of the cell and cause it to hyperpolarize. In its hyperpolarized state, action potentials cannot be fired as quickly as possible, which slows the heart rate. |
Ontology: | GO: Biological Process [GO:0086095] QuickGO AmiGO |