Term Name: | iNOS-S100A8/A9 complex |
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Synonyms: | |
Definition: | A protein complex capable of stimulus-inducible nitric-oxide synthase activity. S-nitrosylates cysteine residues in target proteins, a principal mechanism of nitric oxide (NO)-mediated signal transduction. In mammals consists of NOS2, S100A8 and S100A9. S100A9 acts both as an adaptor linking NOS2 to its target and as a transnitrosylase that transfers the nitric oxide moiety from NOS2 to its target, via its own S-nitrosylated cysteine. |
Ontology: | GO: Cellular Component [GO:1990657] QuickGO AmiGO |