Term Name: | Rhino-Deadlock-Cutoff Complex |
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Synonyms: | RDC complex, rhi-del-cuff complex |
Definition: | Protein complex found in Drosophila consisting of the gene products of cuff, del and rhi. It regulates the licensing of transcription of dual-strand PIWI interacting RNA (piRNA) source loci by binding to dual-strand-cluster chromatin, probably via the H3K9me3-binding activity of Rhi. Rhi binding brings the putative termination cofactor Cuff in close proximity to the nascent piRNA precursor transcript which it appears to protect from degradation. |
Ontology: | GO: Cellular Component [GO:1990469] QuickGO AmiGO |