Term Name: | multi-pass translocon complex |
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Synonyms: | MPT complex, TMCO1 translocon |
Definition: | A protein complex that mediates the insertion of multi-pass transmembrane proteins into endoplasmic reticulum (ER) membrane. Substrates enter via the lateral gate of the Sec61 translocon. The complex comprises the GEL subcomplex (composed of RAB5IF/OPTI and TMCO1), the BOS subcomplex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT subcomplex (composed of WDR83OS/Asterix and CCDC47). |
Ontology: | GO: Cellular Component [GO:0160064] QuickGO AmiGO |