Term Name: | 2-(3-amino-3-carboxypropyl)histidine synthase complex |
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Synonyms: | Dph1-Dph2 complex |
Definition: | A protein complex capable of catalysing the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the histidine residue of translation elongation factor 2 (EF2), which is the first step in the biosynthesis of diphthamide. The complex is a Dph2 homodimer in archaea and a Dph1-Dph2 heterodimer in eukaryotes. |
Ontology: | GO: Cellular Component [GO:0120513] QuickGO AmiGO |