Term Name: | extrinsic apoptotic signaling pathway |
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Synonyms: | death receptor-mediated apoptosis, extrinsic apoptosis, extrinsic apoptotic pathway, extrinsic apoptotic signaling pathway in presence of ligand, extrinsic apoptotic signalling pathway |
Definition: | The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. |
Ontology: | GO: Biological Process [GO:0097191] QuickGO AmiGO |