| Synonyms: |
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity,
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity,
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity,
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity,
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity,
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity,
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity,
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming),
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity,
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity,
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity,
BAL activity,
bile acid CoA ligase activity,
bile acid coenzyme A ligase activity,
cholate thiokinase activity,
cholate:CoA ligase (AMP-forming),
cholic acid:CoA ligase activity,
cholic thiokinase activity,
choloyl coenzyme A synthetase activity,
choloyl-CoA synthetase activity,
cholyl-CoA synthetase activity,
THCA-CoA ligase activity,
trihydroxycoprostanoyl-CoA synthetase activity
|
| Definition: |
Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA. This reaction is the first step in the conjugation of bile acids with amino acids, converting bile acids into their acyl-CoA thioesters. Chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate can also act as substrates. |