Term Name: | T/G mismatch-specific endonuclease activity |
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Synonyms: | DNA mismatch endonuclease, V.EcoKDcm, very short patch repair protein, Vsr mismatch endonuclease |
Definition: | Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine. |
Ontology: | GO: Molecular Function [GO:0043765] QuickGO AmiGO |