Term Name:	symbiont-mediated suppression of host ISG15-protein conjugation
Synonyms:	suppression by virus of host ISG15 activity, suppression by virus of host ISG15-protein conjugation
Definition:	Any process in which a symbiont inhibits or disrupts a host ubiquitin-like protein ISG15 conjugation to a substrate. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. For example, some viruses escape the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15, while the papain-like protease from the coronavirus cleaves ISG15 derivatives.
Ontology:	GO: Biological Process [GO:0039579]    QuickGO    AmiGO