Term Name: | peptide bond cleavage involved in epidermal growth factor receptor ligand maturation |
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Synonyms: | EGFR ligand maturation by peptide bond cleavage, EGFR ligand processing, epidermal growth factor receptor ligand processing, peptide bond cleavage involved in EGFR ligand maturation |
Definition: | The hydrolysis of a peptide bond or bonds within a ligand for the epidermal growth factor receptor, as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein. In Drosophila for example, in the Golgi apparatus of the signal producing cell, Spitz is cleaved within its transmembrane domain to release a functional soluble extracellular fragment. |
Ontology: | GO: Biological Process [GO:0038005] QuickGO AmiGO |