Term Name: | Mis6-Sim4 complex |
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Synonyms: | Mcm21, Mis6 centromere subcomplex, Mis6-Mal2-Sim4 centromere complex, Sim4 complex |
Definition: | A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. |
Ontology: | GO: Cellular Component [GO:0031511] QuickGO AmiGO |