Term Name: | replication fork protection complex |
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Synonyms: | fork pausing complex, Swi1-Swi3 complex, TIMELESS-TIPIN complex |
Definition: | A heterotrimeric replication-pausing complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling. Required for maximal fork speed both in vivo and in vitro. |
Ontology: | GO: Cellular Component [GO:0031298] QuickGO AmiGO |