Term Name:	histone deacetylase activity, NAD-dependent
Synonyms:	histone deacetylase activity, NAD-dependent histone deacetylase activity, NAD-dependent histone lysine deacetylase activity, SIR2, sirtuin
Definition:	Catalysis of the reaction: N(6)-acetyl-L-lysyl-[histone] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a histone to NAD, producing nicotinamide.
Ontology:	GO: Molecular Function [GO:0017136]    QuickGO    AmiGO