Term Name: I-kappaB phosphorylation
Synonyms: IkappaB phosphorylation, IKB phosphorylation, inhibitor of kappaB phosphorylation, inhibitor of NF-kappaB phosphorylation
Definition: The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Ontology: GO: Biological Process [GO:0007252]    QuickGO    AmiGO

Relationships
is part of: canonical NF-kappaB signal transduction
has parts: IkappaB kinase activity
is a type of: protein phosphorylation
negatively regulated by: negative regulation of I-kappaB phosphorylation
positively regulated by: positive regulation of I-kappaB phosphorylation
regulated by: regulation of I-kappaB phosphorylation