Term Name: mitotic spindle assembly checkpoint signaling
Synonyms: Dma1-dependent checkpoint, Mad2-dependent checkpoint, mitotic cell cycle spindle assembly checkpoint, mitotic spindle assembly checkpoint, mitotic spindle assembly checkpoint signalling, SAC-independent checkpoint, signal transduction involved in Dma1-dependent checkpoint, signal transduction involved in mitotic cell cycle spindle assembly checkpoint, signal transduction involved in mitotic spindle assembly checkpoint, signal transduction involved in SAC-independent checkpoint, signaling cascade involved in Dma1-dependent checkpoint, signaling cascade involved in SAC-independent checkpoint, signaling pathway involved in Dma1-dependent checkpoint, signaling pathway involved in SAC-independent checkpoint, signalling cascade involved in Dma1-dependent checkpoint, signalling cascade involved in SAC-independent checkpoint, signalling pathway involved in Dma1-dependent checkpoint, signalling pathway involved in SAC-independent checkpoint
Definition: A mitotic cell cycle checkpoint that delays mitotic sister chromatid separation and consequently the mitotic metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. Spindle assembly checkpoint signaling begins with the activated Mph family kinase, and results in the inhibition of the Anaphase Promoting Complex and its activator Sleepy/Cdc20 by the mitotic checkpoint complex (MCC).
Ontology: GO: Biological Process [GO:0007094]    QuickGO    AmiGO

Relationships
is part of: mitotic cell cycle
is a type of: mitotic spindle checkpoint signaling negative regulation of mitotic metaphase/anaphase transition spindle assembly checkpoint signaling
negatively regulated by: negative regulation of mitotic spindle assembly checkpoint signaling
positively regulated by: positive regulation of mitotic cell cycle spindle assembly checkpoint
regulated by: regulation of mitotic cell cycle spindle assembly checkpoint