Term Name: | 7-methylguanosine mRNA capping |
---|---|
Synonyms: | 5' end capping, 5' mRNA capping, 5'-end mRNA processing, 5'-end processing, mRNA capping |
Definition: | The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively. |
Ontology: | GO: Biological Process [GO:0006370] QuickGO AmiGO |