Term Name:	CAAX-protein geranylgeranyltransferase activity
Synonyms:	geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity, geranylgeranyltransferase type I activity, GGTase-I activity, GGTaseI activity, protein geranylgeranyltransferase type I, type I protein geranyl-geranyltransferase activity
Definition:	Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
Ontology:	GO: Molecular Function [GO:0004662]    QuickGO    AmiGO