Term Name:	second spliceosomal transesterification activity
Synonyms:	3'-splice site cleavage, exon ligation, lariat formation, 5'-splice site cleavage
Definition:	Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.
Ontology:	GO: Molecular Function [GO:0000386]    QuickGO    AmiGO