Term Name:	hereditary combined deficiency of vitamin K-dependent clotting factors
Synonyms:	hereditary combined deficiency of factors II, VII, IX and X, VKCFD
Definition:	A blood coagulation disease characterized by reduced hepatic gamma-carboxylation of glutamic acid residues of all vitamin K-dependent blood coagulation factors and the anticoagulant factors protein C and protein S resulting in a bleeding tendency that is usually reversed by oral administration of vitamin K that has_material_basis_in a heritable mutation.
Ontology:	Human Disease [DOID:0112172]   ( DOID:0112172 )