| Term Name: | pre-B-I cell |
|---|---|
| Synonyms: | pre-BI cell, pro-B cell (Philadelphia nomenclature) |
| Definition: | A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein. |
| Ontology: | Cell Ontology [CL:0000956] |