Term Name: proguanil
Synonyms: 1-(p-chlorophenyl)-5-isopropylbiguanide, Chlorguanide, Chloroguanide, N-(4-Chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(propan-2-yl)imidodicarbonimidic diamide, proguanil, proguanilum
Definition: A biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P. vivax within the red blood cells.
Ontology: Chebi [CHEBI:8455]

Relationships
is a type of: biguanides monochlorobenzenes
has_role: antimalarial antiprotozoal drug EC 1.5.1.3 (dihydrofolate reductase) inhibitor