Term Name: CM-272
Synonyms: 6-methoxy-2-(5-methyl-2-furanyl)-N-(1-methyl-4-piperidinyl)-7-[3-(1-pyrrolidinyl)propoxy]-4-quinolinamine, 6-methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-[3-(pyrrolidin-1-yl)propoxy]quinolin-4-amine, CM 272, CM272
Definition: A member of the class of aminoquinolines that is is quinoline substituted by 5-methylfuran-2-yl, (1-methylpiperidin-4-yl)amino, methoxy, and 3-(pyrrolidin-1-yl)propoxy groups at positions 2, 4, 6 and 7, respectively. It is a dual G9a/DNA methyltransferases inhibitor with antitumor activity. It inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP (IC50 = 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively).
Ontology: ChEBI [CHEBI:229970]  ( EBI )

Relationships
is a type of: aminoquinoline aromatic ether diether furans N-alkylpyrrolidine piperidines secondary amino compound tertiary amino compound
has_role: antineoplastic agent apoptosis inducer EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase] inhibitor EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor ferroptosis inducer