Term Name: alisertib
Synonyms: 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl]amino]-2-methoxybenzoic acid, 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxybenzoic acid, 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid, alisertib, alisertibum, MLN 8237, MLN-8237, MLN8237
Definition: An organic heterotricyclic compound that is 5H-pyrimido[5,4-d][2]benzazepine substituted by (4-carboxy-3-methoxyphenyl)amino, 2-fluoro-6-methoxyphenyl, and chloro groups at positions 2, 7 and 9, respectively. It is an aurora A kinase inhibitor (IC50 = ~1 nM).
Ontology: ChEBI [CHEBI:125628]  ( EBI )

Relationships
is a type of: methoxybenzoic acid monofluorobenzenes monomethoxybenzene organic heterotricyclic compound organochlorine compound secondary amino compound
has_role: antineoplastic agent apoptosis inducer Aurora kinase inhibitor autophagy inducer