Term Name: erastin
Synonyms: 2-(1-{4-[(4-chlorophenoxy)acetyl]piperazin-1-yl}ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one, 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone
Definition: A member of the class of quinazolines that is quinazolin-4(3H)-one in which the hydrogens at positions 2 and 3 are replaced by 1-{4-[(4-chlorophenoxy)acetyl]piperazin-1-yl}ethyl and 2-ethoxyphenyl groups, respectively. It is an inhibitor of voltage-dependent anion-selective channels (VDAC2 and VDAC3) and a potent ferroptosis inducer.
Ontology: ChEBI [CHEBI:94287]  ( EBI )

Relationships
is a type of: aromatic ether diether monochlorobenzenes N-acylpiperazine N-alkylpiperazine quinazolines tertiary carboxamide
has_role: antineoplastic agent ferroptosis inducer voltage-dependent anion channel inhibitor