Term Name: HMN-214
Synonyms: (E)-4-[2-[2-(N-acetyl-N-[4-methoxybenzenesulfonyl]amino)stilbazole]]1-oxide, (E)-4-[2-[2-[N-acetyl-N-[(p-methoxyphenyl)sulfonyl]amino]phenyl]ethenyl]pyridine 1-oxide, HMN 214, HMN214, IVX 214, IVX-214, IVX214, N-[(4-methoxyphenyl)sulfonyl]-N-[2-[(1E)-2-(1-oxido-4-pyridinyl)ethenyl]phenyl]acetamide, N-[(4-methoxyphenyl)sulfonyl]-N-{2-[(E)-2-(1-oxidopyridin-4-yl)ethenyl]phenyl}acetamide
Definition: An N-sulfonylcarboxamide that is N-[(4-methoxyphenyl)sulfonyl]acetamide in which the hydrogen of the NH group is substituted by a 2-[(E)-2-(1-oxidopyridin-4-yl)ethenyl]phenyl group. It is a potent inhibitor of polo-like kinase 1 (PLK1) that exhibits antineoplastic activity.
Ontology: ChEBI [CHEBI:91440]  ( EBI )

Relationships
is a type of: monomethoxybenzene N-sulfonylcarboxamide olefinic compound pyridine N-oxides
has_role: antineoplastic agent apoptosis inducer EC 2.7.11.21 (polo kinase) inhibitor prodrug