Term Name: | rofecoxib |
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Synonyms: | 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one, Ceoxx, Rofecoxib, rofecoxibum, Vioxx |
Definition: | A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke. |
Ontology: | ChEBI [CHEBI:8887] ( EBI ) |