Term Name: remikiren
Synonyms: N-[(2S,3R,4S)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]-Nalpha-{(2S)-2-[(2-methylpropane-2-sulfonyl)methyl]-3-phenylpropanoyl}-L-histidinamide, Nalpha-[(2S)-2-benzyl-3-(tert-butylsulfonyl)propanoyl]-N-[(2S,3R,4S)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]-L-histidinamide, remikiren, remikirene, remikireno, remikirenum, Ro 42-5892, Ro-42-5892
Definition: An L-histidine derivative that is L-histidine in which one of the amino hydrogens is replaced by a (2S)-2-[(2-methylpropane-2-sulfonyl)methyl]-3-phenylpropanoyl group and the carboxy group is replaced by a [(2S,3R,4S)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]amino group. It is a renin inhibitor which was under development for the treatment of hypertension (now discontinued).
Ontology: ChEBI [CHEBI:8803]  ( EBI )

Relationships
is a type of: cyclopropanes diol L-histidine derivative secondary carboxamide sulfone
has_role: antihypertensive agent EC 3.4.23.15 (renin) inhibitor peptidomimetic vasodilator agent