Term Name: | calotropone |
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Synonyms: | (3beta,12beta,14beta,17alpha)-3,14,17-trihydroxy-20-oxopregn-5-en-12-yl benzoate, 12beta-benzoyloxy-3beta,14beta,17beta-trihydroxypregnane-20-one, 12beta-O-benzoyl-3beta,14beta,17beta-trihydroxypregnane-20-one, 3beta,14beta,17-trihydroxy-20-oxo-17alpha-pregn-5-en-12beta-yl benzoate |
Definition: | A 20-oxo steroid that is 17alpha-pregn-5-en-20-one substituted by a benzoyloxy group at position 12 and hydroxy groups at positions 3, 14 and 17 (the 3beta,12beta,14beta stereoisomer). It is isolated from the roots of Calotropis gigantea and displays inhibitory effects towards chronic myelogenous leukemia K562 and human gastric cancer SGC-7901 cell lines. |
Ontology: | ChEBI [CHEBI:65568] ( EBI ) |