Term Name: bevirimat
Synonyms: (3beta)-3-[(3-carboxy-3-methylbutanoyl)oxy]lup-20(29)-en-28-oic acid, 3-O-(3',3'-dimethylsuccinyl) betulinic acid, bevirimat, bevirimatum, BVM, PA-457
Definition: A pentacyclic triterpenoid obtained by the formal condensation of 2,2-dimethylsuccinic acid with the 3-hydroxy group of betulinic acid. It is isolated from the Chinese herb Syzygium claviflorum. The first in the class of HIV-1 maturation inhibitors to be studied in humans, bevirimat was identified as a potent HIV drug candidate and several clinical trials were conducted, but development into a new drug was plagued by numerous resistance-related problems.
Ontology: ChEBI [CHEBI:65484]  ( EBI )

Relationships
is a type of: dicarboxylic acid monoester monocarboxylic acid pentacyclic triterpenoid
has_functional_parent: betulinic acid
has_role: HIV-1 maturation inhibitor metabolite