Term Name:	2-methyl-6-(phenylethynyl)pyridine
Synonyms:	2-methyl-6-(phenylethynyl)pyridine, 6-Methyl-2-(phenylethynyl)pyridine, MPEP
Definition:	A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.
Ontology:	ChEBI [CHEBI:64159] ( EBI )

Relationships

is a type of:	acetylenic compound methylpyridines
has_parent_hydride:	acetylene
has_role:	anxiolytic drug metabotropic glutamate receptor antagonist
inverse is_conjugate_acid_of:	2-methyl-6-(phenylethynyl)pyridinium(1+)
is_conjugate_base_of:	2-methyl-6-(phenylethynyl)pyridinium(1+)