| Synonyms: |
2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine,
2-Fluoro-ARA AMP,
2-Fluoroadenine arabinoside 5'-monophosphate,
2F-ara-AMP,
9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate,
9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate),
9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate,
FAMP,
Fludara,
Fludarabine 5'-monophosphate,
Fludarabine monophosphate
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| Definition: |
A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas. |