Term Name: | polymyxin |
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Synonyms: | polymixin, polymycin, polymyxins |
Definition: | Polymyxins are antibiotics with a general structure consisting of a cyclic peptide with a long hydrophobic tail. They disrupt the structure of the bacterial cell membrane by interacting with its phospholipids. Polymyxins are produced by the Gram-positive bacterium Bacillus polymyxa and are selectively toxic for Gram-negative bacteria. |
Ontology: | ChEBI [CHEBI:59062] ( EBI ) |