Term Name: suramin
Synonyms: 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID, 8,8'-{carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]}dinaphthalene-1,3,5-trisulfonic acid, Belganyl, Naganol, Naphuride, Suramin
Definition: A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Ontology: ChEBI [CHEBI:45906]  ( EBI )

Relationships
is a type of: naphthalenesulfonic acid phenylureas secondary carboxamide
has_functional_parent: naphthalene-1,3,5-trisulfonic acid
has_role: angiogenesis inhibitor antinematodal drug antineoplastic agent apoptosis inhibitor EC 2.7.11.13 (protein kinase C) inhibitor GABA antagonist GABA-gated chloride channel antagonist purinergic receptor P2 antagonist ryanodine receptor agonist trypanocidal drug
inverse is_conjugate_base_of: suramin(6-)
is_conjugate_acid_of: suramin(6-)