Term Name: 4-phenylbutyric acid
Synonyms: 4-PHENYL-BUTANOIC ACID, 4-Phenyl-n-butyric acid, 4-phenylbutanoic acid, Benzenebutyric acid, gamma-Phenyl-n-butyric acid, gamma-phenylbutyric acid, omega-Phenylbutanoic acid, omega-phenylbutyric acid, PBA
Definition: A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Ontology: ChEBI [CHEBI:41500]  ( EBI )

Relationships
is a type of: monocarboxylic acid
has_functional_parent: butyric acid
has_role: antineoplastic agent apoptosis inducer EC 3.5.1.98 (histone deacetylase) inhibitor prodrug
inverse is_conjugate_base_of: 4-phenylbutyrate
is_conjugate_acid_of: 4-phenylbutyrate