Term Name:	D-cycloserine
Synonyms:	(+)-4-amino-3-isoxazolidinone, (+)-cycloserine, (4R)-4-aminoisoxazolidin-3-one, (R)-4-AMINO-ISOXAZOLIDIN-3-ONE, alpha-Cycloserine, cicloserina, cyclo-D-serine, cycloserine, cycloserinum, D-(+)-cycloserine, D-4-amino-3-isoxazolidinone, D-4-amino-3-isoxazolidone, D-Cycloserine, DCS, orientomycin, PA 94, PA-94, Ro-1-9213, Seromycin
Definition:	A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis).
Ontology:	ChEBI [CHEBI:40009]  ( EBI )