Term Name:	phorbol ester
Synonyms:	phorbol ester
Definition:	Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.
Ontology:	ChEBI [CHEBI:37532] ( EBI )

Relationships

is a type of:	carboxylic ester diterpenoid tetracyclic diterpenoid
has subtype:	4-deoxyphorbol 12-acetate 13-(2Z,4E,6E)-deca-2,4,6-trienoate 4alpha-phorbol 12,13-didecanoate 12-deoxyphorbaldehyde-13-hexadecanoate 12-deoxyphorbol 20-acetate 13-(2-methylbutanoate) 12-deoxyphorbol-13,20-diacetate 12-deoxyphorbol-13-(3E,5E-decadienoate) 12-deoxyphorbol-13-hexadecanoate 12-O-Decanoylphorbol-13-acetate 12b-O-[Deca-2Z,4E-dienoyl]-13a-isobutyl-5-ene-7-oxo-4b-phorbol 16-hydroxyphorbol 13-decanoate 12-palmitate [(1S,6R,10S,13S,14R,15R)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-14-[(E)-2-methylbut-2-enoyl]oxy-5-oxo-13-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] 2-methylbutanoate [1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-13-(2-methylpropanoyloxy)-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] (E)-2-methylbut-2-enoate [13-acetyloxy-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] (E)-2-methylbut-2-enoate Candletoxin A LSM-4341 pedilstatin phorbol 12,13-dibutanoate phorbol 13-acetate phorbol 13-acetate 12-myristate phorbol 13-butanoate phorbol 13-decanoate 12-tiglate prostratin rel-12-O-(4Z)-Deca-4-enoylphorbol-13-acetate rel-12-O-(4Z,7Z)-Deca-4,7-dienoylphorbol-13-acetate rel-12-O-Octanoylphorbol-13-acetate rel-16-Angeloyloxy-13alpha-isobutanoyloxy-4beta,9alpha,7beta-trihydroxytiglia-1,5-dien-3-one rel-16-Angeloyloxy-13alpha-isobutanoyloxy-4beta,9alpha,20-trihydroxytiglia-1,5-diene-3,7-dione sapintoxin D tigilanol tiglate
has_functional_parent:	phorbol