Term Name: | doxifluridine |
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Synonyms: | 1-(beta-D-5-desoxyribofuranoxyl)-5-fluoruracil, 5'-deoxy-5-fluorouridine, 5'-Dfur, 5'-dFUrd, 5-fluoro-5'-deoxyuridine, doxifluridina, doxifluridine, doxifluridinum, Furtulon, Ro 21-9738, Ro 219738 |
Definition: | A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluorouracil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase. |
Ontology: | ChEBI [CHEBI:31521] ( EBI ) |