| Synonyms: |
2',4,8-Trimethylpsoralen,
2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one,
4,5',8-Trimethylpsoralen,
4,8,5'-Trimethylpsoralen,
6-hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone,
Trimethylpsoralen,
trioxisaleno,
Trioxsalen,
trioxysalen,
trioxysalene,
trioxysalenum
|
| Definition: |
7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis. |