Term Name: aphidicolin
Synonyms: (3alpha,4alpha,5alpha,17alpha)-3,17-dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol, Aphidicolin, aphidocolin
Definition: A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.
Ontology: ChEBI [CHEBI:2766]  ( EBI )

Relationships
is a type of: tetracyclic diterpenoid
has_role: antimicrobial agent antimitotic antineoplastic agent antiviral drug apoptosis inducer Aspergillus metabolite DNA synthesis inhibitor EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor fungal metabolite